Endocrine Abstracts

Introduction: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. A female appearance patient with secondary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. We here report a case of a 16- year-old girl with secondary amenorrhea and 46 XY karyotype after bone marrow transplantation (BM...

Introduction: Graves’ disease GD is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes. Though quite rare, this disease can also manifest with lymphoid hyperplasia.Case report: Two cases are reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia from 2006 to 2016 associated GD with lymphoid hyperplasia reaction. The first case was a 32 years old male with history...

Introduction: Autoimmune thyroid diseases are known to be associated with oxidative stress.Objectives: We studied the oxidative profiles in plasma and thyroid tissue of 82 patients having Graves’ disease (GD) or Hashimoto thyroiditis (HT) or hashitoxicosis (HTX) vs 65 healthy controls in order to evaluate the antioxidant enzymes’ activity and the lipid peroxidation.Results: The lipid peroxidation was objected with a signi...

Introduction: Diabetic foot infection (DFI) is a major public health problem, both for its morbid clinical consequences mainly ulcers and the economic social cost due to repeated hospitalisations and the high rate of amputation.Objectives: Analyse the clinical presentation of DFI, study risk factors of developing this infection and describe the therapeutic management.Materials and methods: Retrospective study spread over 8 years ol...

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. PA is a clinical syndrome characterized by the sudden onset of headache, vomiting, visual impairment and decreased consciousness in some cases. The objectives of our study are to describe its clinical features and characterize the visual impairments in a cohort of PA in the region of Sfax.Methods: It is a retrospective...

Diabetes is a factor favoring infections. Among which, the sepsis that becomes formidable and serious on this ground. The purpose of our work is to study the clinical, therapeutic and evolutionary features of sepsis in diabetics. A retrospective study of 43 cases of septicemia in diabetic patients collected at the service of Sfax Infectious Diseases. There were 22 men and 21 women, mean age 59 (20–78) years. Community origin was present in 88.4% of cases and nosocomial in...

Introduction: Primary amyloidosis is a multi-systemic disease difficult to identify given the diversity of the disorders that it can cause especially at an early stage of the disease. This makes its diagnosis difficult in case of association with a pathology that can be intricate with its clinical expression. In this context we report the first case in the literature associating mitochondrial diabetes (DM) with a primary amyloidosisCase: A 32 years old g...

Introduction: Deficiency of 17-βHSD3 is a rare autosomal recessive disorder of sex development manifesting in XY karyotype individuals. The presentation can range from partial or incomplete virilisation at birth to primary amenorrhoea and virilisation at puberty of an externally phenotypically female individual.Case reports: Case1 A 2-year-old girl presented with ambiguity of external genetalia. She had no significant past medical or surgical histor...

IntroductionUncontrolled hyperglycemia of diabetes is a common cause of renal failure and diabetic nephropathy, which is also called diabetic kidney disease (DKD). Despite improvements in the management of type 1 diabetes (T1D), progression of diabetic nephropathy remains unpredictable and associated with high morbidity and mortality. The objective of this study is to assess the prevalence and risk factors for diabetic kidney disease among adults-onset T...

Sexual differentiation is a sequential process where several genes are involved, therefore a defect at any stage can lead to a divergence between genetic, gonadal and phenotypic sex. The objective of our work is to analyze the clinical and hormonal characteristics of 13 XY patients, explored between 1989 and 2007 and belonging to 10 different families. The average age of our patients was 18.9 years (2–33 years). The reason for consultation was sexual ambiguity in two case...